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The FAERS database is subject to reporting bias, lacks denominator data (total number of patients exposed), and cannot distinguish between coincidental associations and true drug-related effects

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In terms of actual lung disease, a possible scenario may be that symptoms, including excessive inflammation and oxidative stress, may be tied to these adaptive responses and may only begin to arise when these adaptive responses fail

If existing gallstones are found without symptoms (asymptomatic cholelithiasis), semaglutide is usually still safe, though closer monitoring becomes essential