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In the case of Apert syndrome, for example, there is good reason to believe that the causative mutation (in this case, predominantly a 755C-G transversion in the FGFR-2 gene) arises in spermatogonia and is selectively retained in the germinal epithelium because the mutant germ cells enjoy an unspecified selective advantage [4]

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Most patients do not require any time off from work, and may even return to work on the same day.

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However, that energy effect is only true to the extent that they were B12 deficient in the first place