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Major classes of ADP-ribosyltransferases include: (1) glycohydrolases (NADases that break nucleotides into nucleosides and phosphate) (2) ADP-ribosylases (ADP-ribosylation that add one or more ADP-ribose moieties to a protein), and (3) deacetylases (deacetylations that remove an acetyl group)

The peptide powerfully modulates inflammation by increasing microRNA-146a expression while decreasing pro-inflammatory cytokines including TNF-alpha, IL-6, IRAK1, and TRAF6