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PBMCs donated by ME/CFS patients (mix of moderate and severe ME/CFS donors), and healthy controls were incubated in the donors own plasma, which was increased to a concentration of 200 mM/L NaCl to impart hyperosmotic stress on the cells

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doi: 10.1016/j.amsu.2021.102917

10.1164/rccm.200212-1479SO

Interestingly, analogous redox-proteostasis interactions occur in plants, where GLR-mediated Ca 2+ influx and NO production have been shown to affect ER and mitochondrial homeostasis (Forrester et al

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