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Common cleavable linkers include acid-cleavable linkers (e.g., hydrazone), pH-sensitive linkers, enzyme-cleavable linkers (peptide linkers, such as Cathepsin B-sensitive sequences), disulfide linkers, and redox-sensitive linkers triggered by reductive environments

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Intestinal absorption pathway As a polypeptide substance, IGF-1 LR3 is mainly absorbed in the intestine through two pathways: one is the transcellular pathway, where epithelial cells phagocytose IGF-1 LR3 into the cell to form an endosome

These changes suggest a protective effect against exercise-induced muscle damage (11)

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Basic Res Cardiol 112(4):45