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8) Obesity Higher activity of the FMO3 enzyme, responsible for producing TMAO, was associated with higher body mass index (BMI), waist-to-hip ratio, and body fat, but lower insulin sensitivity, in 770 men [37]

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1 In this study, adverse events considered possibly to be caused by hydroxocobalamin were chromaturia (n=5), pink-to-red skin discoloration (n=3), increase in heart rate (n=1), and elevated blood pressure (n=1)

Petersen, J., Merrild, C., Lund, J., Holm, S

Umehara et al., 2022)

Registered dietitian consultation may benefit patients with significant dietary challenges or rapid weight loss