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Patient-derived glioblastoma organoids have been used to model glioblastoma, allowing for both biobanking and orthotopic transplantation of intact organoids into mice [161]
These findings collectively validate that precise intervention in this axis may markedly augment chemotherapeutic efficacy, though the successful clinical translation of such combinations require careful patient stratification based on molecular and histological subtypes
on the other hand, heterochromatinization is characterized by higher levels of H3K9me2/3, H3K27me2/3 and H4K20me3
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