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Epidemiological studies often dont find a statistical, population-wide link between the introduction of the HPV vaccine and the number of POTS diagnoses.[ref][ref] Additionally, some researchers point to media coverage as a cause for any post-vaccination symptom spikes.[ref] Does long Covid cause POTS

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Activation of the IRE1-XBP1 pathway is essential for ER expansion and antibody secretion in plasma cells, further implicating ER stress in SLE pathogenesis

Nature 623 (7987), 580587