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Dejgaard, T

Red Flags Nausea on GLP-1 Therapy: When It Is a Dose Issue and When It Needs Attention Nausea is one of the most common side effects patients ask about during GLP-1 therapy

Jay said shes seen this in her own practice

JAMA 334 , 12311234 (2025)

Potential Negative Effects on Mental Health While the potential benefits are encouraging, its crucial to acknowledge the potential negative impacts of GLP-1 inhibitors on mental health: Increased Anxiety and Agitation: Paradoxically, while some studies suggest anxiety reduction, others have reported instances of increased anxiety, restlessness, and agitation in individuals taking GLP-1 agonists

N Engl J Med 369: 1317-1326, 2013