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The BUD is conservative by design, intended to ensure sterility and potency within a validated window

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Nausea, diarrhea, and vomiting were the most common events

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2 Thus, there is a tremendous amount of research under way to further elucidate these mechanisms and, more important, to discover pharmacologically based strategies that correct these separate, but intertwined, physiologic derangements

The proportional hazards assumption was evaluated by examining the scaled Schoenfeld residuals of each variable ( Finally, to examine a possible additive effect of GLP-1 RAs on fracture risk, we used Aalens additive hazards regression model