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The choice depends on your health goal, because both support glutathione differently

Regulatory note: The FDA added injectable GHK-Cu to a high-risk compounded substance list in September 2023

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Unlike some harsher actives that degrade collagen to trigger a healing response, GHK-Cu appears to gently signal fibroblasts to produce more structural proteins

The approach to anaphylactoid reactions due to N-acetylcysteine is discussed further below

Hasanuzzaman M, Fujita M (2011) Selenium pretreatment upregulates the antioxidant defense and methylglyoxal detoxification system and confers enhanced tolerance to drought stress in rapeseed seedlings