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During HFD feeding, mice lacking the circadian clock in adipocytes gained excess body weight and had impaired glucose homeostasis, which is consistent with prior results 8,11 (Fig

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An analog like IGF-1 LR3 that binds IGFBPs poorly does not join the large protected reservoir, but the fraction that is free and bioactive is dramatically higher, and critically in laboratory and animal systems that free analog is not being continually captured and buffered by binding proteins

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