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Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

The ratio of reduced to oxidized glutathione serves as a key indicator of the cellular redox potential, with even small changes in the GSH:GSSG ratio influencing protein function by altering cysteine oxidation and disulfide bond formation (Romero-Aristizabal et al., 2014)

doi: 10.4103/13193767.111956 177 EraldemirFCMusulMDumanAEOztasBBaydemirCHulaguS

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The ability of Epitalon to permeate the cell membrane and enter the nucleus has been demonstrated [20], thus suggesting that its activity may be associated with cytoplasmic and nuclear components

10.1016/j.biopha.2017.06.010 Biomed