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102 Compared with the structure of human GLP-1(7-36), the amino acid sequence of albiglutide contains an arginine at position 8 (in GLP-1, this residue is lysine), and two modified GLP-1 peptide chains are fused to human serum albumin (HSA), thereby greatly extending its half-life

This triggers a cascade of beneficial effects such as increased insulin secretion, improved glucose uptake, and a sensation of satiety, making them valuable in managing metabolic disorders like diabetes and obesity

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

GLP-1 triggers the release of insulin from your pancreas

Acting on appetite centers in the brain

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