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While oral formulations offer non-invasive dosing, their low bioavailability and potential gastrointestinal side effects have remained major limitations

17 35 Therefore, careful clinical monitoring is warranted, especially during the early phases of treatment

Meanwhile, in January 1996 the first rodent study suggested that GLP-1 could be a central regulator of feeding behavior and satiety based on intracerebroventricular injection studies [4], but soon thereafter the results of other rodent studies using peripherally injected GLP-1 argued against an appetite effect [5]

However, while semaglutide can be an effective tool, it is not a stand-alone solution