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Superior weight loss with once-weekly semaglutide versus other glucagon-like peptide-1 receptor agonists is independent of gastrointestinal adverse events

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And people who stopped using the medications were significantly less optimistic about their benefits: Only about half of those who had used injectable weight-loss drugs in the past said they were effective, compared with nearly three-quarters of those who were actively using the treatments

High blood sugar and insulin resistance create a state of constant, low-grade inflammation

Mller et al., 2019)

As this review makes clear, the reference standard itself carries substantial, often unacknowledged, uncertainty