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Abbreviations SJS: Stevens-Johnson Syndrome TEN: Toxic Epidermal Necrolysis FT1DM: Fulminant Type 1 Diabetes Mellitus IVIG: Intravenous immunoglobulin SCARs: Severe cutaneous adverse reactions DRESS: Drug reaction with eosinophilia and systemic symptoms AGEP: Acute generalized exanthematous pustulosis References Bastuji-Garin S, Rzany B, Stern RS, et al

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Given the consequences of genotoxic stress, counteracting DNA damage in the body may take the form of firstly, DNA repair mechanisms being enhanced, or secondly, preventing DNA damage through strengthening the integrity of the epidermal barrier between UVR and our UV-labile molecular components

These enzymes maintain the mitochondrial antioxidant defenses ( The tricarboxylic acid (TCA) cycle occurs in the mitochondria is essential for ATP energy supplement and participates in multiple mitochondria metabolic pathways ( Figure 1 )