Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant
The abstract does not include the specifics for these endpoints, only stating that there were significant improvements. Eli Lilly previously disclosed in a press release, that they expected patients using tirzepatide to lose between 18-20% of their body weight
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However, it also has been found to be associated with insulin resistance syndrome including obesity, fat distribution, hypertension, dyslipidemia, and cardiovascular disease [48]
BV2 cells were treated with GLP-1RAs, including exendin-4 and tirzepatide
