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Cohort 1 (active from June 2025) covers adults with a BMI of 40 or higher and at least four weight-related conditions

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

Its 2022 disclosure by Coskun and colleagues (Cell Metabolism) marked a deliberate extension of the dual-incretin agonist concept pioneered by tirzepatide, adding glucagon receptor engagement to the pharmacological palette

Science (2017) 357:50711

We also evaluated whether GLP-1R and PKA signalling were involved in the protective effect of metformin in HUVECs

Although glyphosate has been classified as a potentially carcinogenic substance (Guyton et al., 2015) and has been linked to psychiatric symptoms and neurotoxicity (Costas-Ferreira et al., 2022) the debate on glyphosate's detrimental effects on human health continuously persists in the scientific community with scarce number of studies and inconsistent findings