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As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively

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Even though these results suggest that the tested bacterial strains do not display a predominant role in the thiomethyl shunt as opposed to the liver, further experiments with the gut microbiota will be needed to confirm these results

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