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In another article, GA was shown to alter TGF-/Smad signaling pathway, thereby modifying dimethylnitrosamine-induced liver fibrosis in rats (Perazzoli et al., 2017)

They inform biological hypotheses but do not establish clinical efficacy in humans

Glutathione deficiency has been associated with impaired immune responses in some studies

Availability of data and materials No data was used for the research described in the article

Marques J, Fernandez-Irigoyen J, Ainzua E, Martinez-Azcona M, Cortes A, Roncal C, Orbe J, Santamaria E, Zalba G (2022) NADPH oxidase 5 (NOX5) overexpression promotes endothelial dysfunction via cell apoptosis, migration, and metabolic alterations in human brain microvascular endothelial cells (hCMEC/D3)

In the future, caffeine may be developed as a drug to prevent and treat liver diseases