when to stop tirzepatide before surgery It’s not because the GLP-1 medication itself is dangerous during anesthesia…, it’s because of how it affects gastric emptying, The practice around GLP-1’s and anesthesia is ever changing, however. , Do I Need To Stop

Effects beyond 68 weeks

A 2025 Nature Communications study (Mastaitis et al

de Freitas Cayres LC, de Salis LVV, Rodrigues GSP, van Lengert AH, Biondi APC, Sargentini LDB et al (2021) Detection of alterations in the gut microbiota and intestinal permeability in patients with Hashimoto thyroiditis

If other measures prove ineffective, switching to a different GLP-1 medication or discontinuing them altogether may be the best solution

PMID: 22682224 | doi:10.1016/j.cmet.2012.04.022 Yoshino J et al

Traditionally, experts attributed the drugs success to reduced liver glucose production, improved insulin sensitivity, and important contributions from the gut and microbiome