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The specific mechanism by which melanin synthesis is increased is not fully understood, though it is possible that metabolites of some drugs may stimulate melanogenesis

Semaglutide is an FDA-approved medication originally developed for managing blood sugar levels in people with type 2 diabetes

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The use of rat organotypic hypothalamic slices confirmed that AMPK activity at low glucose concentrations was stimulated, and S6K activity was maintained with minimal activation [83]

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