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This regenerative capacity is fundamental to maintaining tissue health and preventing the accumulation of cellular damage over time

The increase in plasma osmolarity also results in increased loss of potassium and sodium in the urine due to an osmotic diuresis, and the development of a net loss of total body stores of potassium, even though the plasma level of potassium may be normal or elevated

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J Cardiovasc Pharmacol 58:157166

In keloids, it disrupts the FOXO4-p53 interaction, inducing apoptosis in senescent fibroblasts and reducing pro-inflammatory and mesenchymal fibroblast subpopulations

Nausea, vomiting, and diarrhea are common, and depending on the person there are real risks of acute kidney injury, gallstones, and pancreatitis, plus muscle and bone loss in older adults