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Furthermore, the dual-luciferase activity of miR-146a-3p and AQP4 was significantly down-regulated, which indicated the direct effect of miR-146a-3p with AQP4

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For up to two years, 199 premenopausal women received part in the study

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Authors proposed a model wherein PL enters the cell, is hydrolyzed in its active form (hPL) with subsequent formation of a hPL:GSH complex that binds the active site of GSTP1-1 causing its inhibition (Fig