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The occurrence of ferroptosis is related to the metabolism of iron, amino acids, GSH, reactive oxygen species (ROS), and lipid peroxides (LPOs)

A study evaluating different antioxidants found that, in controlled doses, glutathione reduces cell oxidation levels by up to 30% more than vitamin C and by 20% more than vitamin E after four weeks' use 1

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Second, the successful clinical translation of SFN depends fundamentally on overcoming the substantial interindividual variability in its bioavailability and metabolism