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[21] Additionally, melatonin binding to MT1 receptors may influence calcium channel activity and potassium channel conductance, further contributing to its sleep-promoting effects

Furthermore, it is important to note that our findings here specifically reflect the pharmacological profile of the triagonist IUB447, characterised by Finan et al

In models of lung and breast cancer, targeting Apelin prevented resistance associated with anti-angiogenic therapy by reducing tumor growth, metastasis and improving vessel function [188]

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