Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al
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Here, we used PURE G4 partially functionalized with lactate molecules (LA) at the surface, a conjugation strategy to direct these nanoparticles to MCT1 expression related to increased glycolysis and complexed with anti- GLS1 small interference RNAs (anti- GLS1 -siRNAs) to target glutamine metabolism in GBM cells
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A unique intracellular enzymatic cascade is involved in the bidirectional conversion of L-cysteine to -glutamyl-L-cysteine to -L-glutamyl-L-cysteinylglycine (GSH) 75,76,77
