With intramuscular injections of B12, any excess will result in high levels within your blood so you may experience side effects such as headache, dizziness, tiredness, or gastrointestinal issues including nausea, until your body has metabolised any excess through your kidneys enroute to excretion via urine
Alkylating agents such as NEM or iodoacetamide can be added to block free thiols and lock the GSH/GSSG ratio at the time of collection
Kowall, J
Medication users need regular followups, lab checks, and dose adjustments
Furthermore, supplementation with spermidine has demonstrated the potential to extend lifespan across various species, foster cardiovascular health, provide neuroprotection, and enhance skeletal muscle regeneration (Madeo et al., 2018)
At the same time, it can promote the repair and regeneration of joint cartilage, reduce joint pain and inflammation, and improve joint mobility