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These medications have undergone extensive clinical trials to evaluate their efficacy and safety in managing type 2 diabetes and, more recently, their potential for weight loss

Safety Profile of Combined Metformin and Semaglutide Use Clinical trials and real-world evidence confirm that metformin and semaglutide can be safely prescribed together with no major drug interactions

Nature 413(6857):739743

Tirzepatide works on two hormonal pathways (GLP-1 and GIP) compared to semaglutide one pathway (GLP-1 only), which clinical data suggests may produce greater weight loss

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