glp-1 antagonist mechanism of action Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP-1 receptor agonists in the

The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 2 M 8-oxo-dGTP, 0.5 M dPTP, 20 PCR cycles Library 2: 2 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 3: 2 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library

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Halestrap AP, Doran E, Gillespie JP, OToole A