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GLP-1 agonists help regulate your appetite and how many calories you eat

Acta 1438 , 167174 (1999)

And then it's there are various discoveries, like, you know, that thyroid produces thyroid hormones that seem to have an effect on metabolism

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doi: 10.1038/nrendo.2012.49, 17

Meta-analyses and randomized trials up through 2024 usually report smaller average weight loss in the single-digit percentage range