Ventral hippocampus In this area we observed that WD increased inflammation in males only, and GE2 treatment reduced inflammation in SD-fed males and females ( Fig
Over-the-counter non-sedating antihistamines such as cetirizine or loratadine may provide symptomatic relief for mild allergic-type itching

The most frequent gastrointestinal side effects include: Nausea and vomiting : Very common, typically most pronounced during dose escalation Diarrhoea : Common to very common, though usually mild to moderate Constipation : Can occur due to delayed gastric emptying and reduced gut motility Abdominal pain and discomfort : Common Dyspepsia and gastro-oesophageal reflux : May worsen in susceptible individuals Other important adverse effects include: Gallbladder disorders : Cholelithiasis and cholecystitis have been reported, particularly with weight loss Dehydration and acute kidney injury : May occur secondary to severe gastrointestinal symptoms Hypoglycaemia : Risk increases when used with insulin or sulfonylureas, which may require dose adjustment Current limited evidence does not suggest an increased risk of inflammatory bowel disease (IBD) flares with GLP-1 agonists, though more data are needed

Zepbound (approved November 2023): for chronic weight management in obesity, or in overweight with a related condition, and since 2024 additionally for obstructive sleep apnea
Yes, but only through narrow channels
The result is meaningful weight loss and better blood sugar, with proven cardiovascular benefit in obese patients on top of that [4]