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While we have not tested the full combination in females, we have tested GDF8 and ActA blockade in lean female monkeys 28 and in postmenopausal women in our Phase 1 clinical study in the accompanying manuscript (Gonzalez Trotter et al

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Analyses were restricted to patients with non-missing values at both timepoints

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Eating smaller, more frequent meals, avoiding high-fat or fried foods, and drinking at least 64 ounces of water daily can help

At that point, the process of the heart maintaining necessary levels of ATP does not meet the demand, and the walls of the LA and LV weaken due to the stress of the volume overload, causing them to stretch and enlarge