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The shift matters because oral GLP-1 weight loss options have the potential to reach millions of patients who have been reluctant to start, or unable to maintain, injectable therapy

The challenge is that stopping suddenly can make hunger, fullness, and digestion shift faster than expected

Monitoring body composition helps keep losses within that safer threshold

It promotes longer satiety, slows gastric emptying, lowers blood sugar, and helps suppress cravings

Muscle preservation strategies become relevant even at the starting dose

Protease-resistant IGFBPs could be a potential therapeutic agent in cancer therapy by preventing the mitogenic activity of IGF