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Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria

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Massa SM, Yang T, Xie Y, Shi J, Bilgen M, et al

For example: Older adults might need more frequent or higher doses because their bodies absorb less and they are more likely to be deficient

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To support 2-HG synthesis, cancer cells with IDH1 R132H mutation enhance NADPH production via the PPP