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In Experiment 1, oocyte viability, early apoptosis, mortality, oxidative status, the mitochondrial membrane potential and distribution, DNA fragmentation, maturation, fertilization, embryo development rates, blastocyst quality and cumulus cell activity were analyzed by factorial ANOVA followed by the Bonferroni post hoc correction

FDA Adverse Event Reporting System analysis revealed significant disproportionate reporting of thyroid cancer with GLP-1 RAs, with reporting odds ratios ranging from 2.09 (tirzepatide) to 15.59 (liraglutide) [189]

SattarNMcGuireDKPavoIWeerakkodyGJNishiyamaHWieseRJet alTirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis

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doi:10.1016/0022-4731(82)90565-9 [14] Roager HM, Hansen LB, Bahl MI, et al