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Managing it means eating low-histamine, fresh foods, going gluten free, avoiding DAO-blocking meds and alcohol, and supporting DAO with nutrients like vitamin C, B6, and copper

Many brands want their serum to contain multiple high-performance actives such as vitamin C derivatives, retinoids, exfoliating acids, botanical antioxidants, or hydrating complexes

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These include compounds that are FDA-approved, have GRAS (Generally Recognized as Safe) status, appear in the USP monograph, or are listed on the FDA's 503A Bulks List

It is possible therefore that a poor gut biome, or indeed even the source of ALCAR/LC may be important in describing outcomes