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If lifestyle changes, and/or subsequent pharmacological treatment did not provide adequate management of diabetes, exogenous insulin treatment was initiated.[6][7][8] Many of these agents either induce weight gain or edema (sufonylurea, insulin, TZDs), or have no significant effect of body weight (metformin, -glucosidase inhibitor), but are associated with some treatment-limiting side effects such as hypoglycaemia (e.g

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