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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)

Research suggests VIP has neuroprotective and neurotrophic properties, supporting bloodbrain barrier integrity, reducing oxidative stress, and modulating neuroinflammation, with relevance in neurodegenerative models such as Alzheimers and Parkinsons disease

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