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The fact that colon cancer is more frequent in patients with inflammatory bowel diseases than in controls supports the link of chronic inflammation and transformation (161)

179 Tayyebi, A., Poursadeghfard, M., Nazeri, M

Studies show it modulates over 4,000 human genes activating those associated with tissue repair and cellular energy, while suppressing genes linked to inflammation and cellular senescence (the "zombie cells" that accumulate in aged tissue and accelerate aging around them)

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Increased NNMT activity has been observed in several metabolic research models and is associated with altered energy expenditure and disrupted NAD+ recycling