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In the STEP UP T2D trial, more than 500 patients with obesity and type 2 diabetes were treated during the same period of time

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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

This effect appears to be driven by anti-inflammatory and proliferative mechanisms independent of receptor activation/signaling in the resident vascular cells [74,75,76]

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