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Except for repression of DNA repair, IGF-IR inhibition may downregulate the synthesis of survivin, a dual regulator of cell proliferation and survival [106]
Therefore, selenium deficiency is associated with thyroid dysfunction and increased risk of thyroid autoimmunity and nodules [65], a condition further aggravated by the fact that concurrent iodine and selenium deficiency is rather common [66, 67]
Research Activity Substrate for glutathione peroxidase and glutathione-S-transferase in in vitro studies
Researchers have shown that a TFR-mediated increase in iron uptake in GCs induces the release of ROS, mitochondrial autophagy, and lipid peroxidation (108)
10.1007/s002280050525 5 BalenovicD.BencicM
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