The precursor literature includes human pharmacokinetic work
Realistic expectations are 0.25-0.5 kg (0.5-1 lb) per week under optimal conditions, with the rate influenced by baseline body composition, dietary habits, activity level, and individual metabolic responsiveness
Has the compound degraded
For individuals with pernicious anaemia or a condition that prevents B12 absorption, injections are medically necessary because oral supplementation will not be absorbed effectively
Crohns disease, for example, increases ones risk for vitamin B12 deficiency, as the portion of the small intestine that normally absorbs B12 (the ileum) is frequently inflamed and/or scarred
Frequently Asked Questions (FAQs) References: Mecobalamin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia [Internet]