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University of North Carolina at Chapel Hill and the United States National Institute of Mental Health

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The most commonly reported effects include: Nausea, especially after starting treatment or increasing the dose Vomiting or stomach discomfort Diarrhea or constipation Reduced appetite and lower calorie intake For many people, these symptoms improve as the body adjusts over the first few weeks

If you are already experiencing significant nausea or stomach discomfort from Saxenda, adding ibuprofen might exacerbate these symptoms