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In the large cardiovascular outcomes trial reported in the Wegovy label, systolic blood pressure fell by a mean of 3.8 mmHg with semaglutide versus 0.5 mmHg with placebo at week 104, a difference of 3.3 mmHg from a baseline of 131 mmHg

(2000) 279:G893902

For uninsured patients, compounded semaglutide from a 503A pharmacy delivers equivalent clinical efficacy at a fraction of the out-of-pocket expense, typically $189 per month versus brand-name copays or cash prices exceeding $900 monthly

"I always think it makes sense to take side effects like that seriously, particularly in drugs that are relatively new and that we're still learning about," says Alpert, who also chairs the American Psychiatric Association's Council on Research

Written by Jordan Weiss and reviewed by Daniel Angerbauer, DO, and republished with permission from Atria Health and Research Institute

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