These findings suggest that the addition of GLP-1 receptor agonists to metformin therapy may mitigate certain serious adverse effects associated with metformin monotherapy
DPP-4 inhibitors in patients with T2D
Increase intensity gradually
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In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)
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