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In general, available pharmacopeial methods commonly used in GMP settings for peptides primarily rely on IP-RPLC, often using nonMS-compatible ion-pairing reagents, with only a few methods employing more MS-compatible alternatives

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[29] Combination drugs [edit] Some DPP-4 inhibitor drugs have received approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production

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