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Start with a modest fasting window (12 hours) and extend gradually if tolerated well

First, GSHee elicited a sustained increase in Ve via the sustained increase in fr that was accompanied by the expected decreases in both Ti and Te, whereas it had minimal effects on Vt

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GIP mediates the incretin effect and glucose tolerance by dual actions on cells and cells

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Once an individual is obese, it becomes challenging to lower weight with exercise and diet alone, highlighting the need for effective medical interventions