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14 Folate, as 5,10- methylenetetrahydrofolate (5,10-methyleneTHF) acts as the cofactor in both the de novo thymidylate and methionine pathways

For Parkinsons disease, the study utilized a unilateral 6-OHDA lesioned rat model

[163], described the case of an athyreotic cretin who showed a refractoriness to high doses of desiccated thyroid when fed soybean formula due to an increased fecal concentration of 131 I-labeled levothyroxine, compared with data obtained from the same child when on a whole milk diet, thus suggesting a possible levothyroxine malabsorption

For this reason, a vitamin B12 overdose is unlikely

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